Adaptive Clinical Trial Designs

Each module will include lectures about the theory of each adaptive trial design and an example of their use in practice. Opportunities to dig deeper and test your knowledge through Q&A and asynchronous interaction with experts and fellow participants through an online forum.

Module 1: General introduction to Ecraid and adaptive trial designs

Module 2: Seamless trial designs & endpoint selection

Module 3: Group sequential designs and sample size re-estimation

Module 4: Response adaptive randomisation and covariate-adjusted response adaptive randomisation designs

Module 5: Platform trials and the personalised randomised controlled trial

Module 6: Ethical and logistical concerns for adaptive designs

Target audience

Those with an interest, or experience, in clinical research or clinical trials with basic statistical knowledge, including hypothesis testing and methods for traditional randomised controlled trials.

Learning outcomes

After following these training modules, participants should be able to:

1. Describe the most relevant types of adaptive trial designs.
2. Explain the advantages and disadvantages of different types of adaptive trial designs.
3. Explain when to use specific types of adaptive trial designs.
4. Appropriately interpret published findings from adaptive trial designs